MYOCD
Gene Information
- Official Symbol: MYOCD
- Official Name: myocardin
- Aliases and Previous Symbols: N/A
- Entrez ID: 93649
- UniProt: Q8IZQ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
- UniProt Summary: Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). {ECO:0000250, ECO:0000269|PubMed:12640126}.
Pfam Domains GO Terms
Pfam Domains
| SAP |
| RPEL |
GO Terms
| positive regulation of cardiac vascular smooth muscle cell differentiation |
| regulation of cell growth by extracellular stimulus |
| regulation of cardiac vascular smooth muscle cell differentiation |
| positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation |
| positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| urinary bladder development |
| negative regulation of platelet-derived growth factor receptor-beta signaling pathway |
| ductus arteriosus closure |
| RNA polymerase II-specific DNA-binding transcription factor binding |
| positive regulation of transcription from RNA polymerase II promoter involved in heart development |
| negative regulation of skeletal muscle cell differentiation |
| positive regulation of vascular smooth muscle cell differentiation |
| negative regulation of vascular associated smooth muscle cell migration |
| regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| regulation of phenotypic switching |
| regulation of platelet-derived growth factor receptor-beta signaling pathway |
| negative regulation of amyloid-beta clearance |
| cardiac muscle cell myoblast differentiation |
| positive regulation of smooth muscle cell differentiation |
| negative regulation of skeletal muscle tissue development |
| cardioblast differentiation |
| negative regulation of platelet-derived growth factor receptor signaling pathway |
| vascular smooth muscle cell differentiation |
| regulation of vascular smooth muscle cell differentiation |
| regulation of transcription from RNA polymerase II promoter involved in heart development |
| ventricular cardiac muscle cell differentiation |
| regulation of amyloid-beta clearance |
| negative regulation of vascular smooth muscle cell proliferation |
| positive regulation of cardiac muscle cell differentiation |
| regulation of skeletal muscle cell differentiation |
| negative regulation of myotube differentiation |
| negative regulation of smooth muscle cell migration |
| regulation of vascular associated smooth muscle cell migration |
| uterus development |
| negative regulation of cardiac muscle cell apoptotic process |
| regulation of platelet-derived growth factor receptor signaling pathway |
| R-SMAD binding |
| negative regulation of striated muscle cell apoptotic process |
| positive regulation of cardiocyte differentiation |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| positive regulation of transforming growth factor beta receptor signaling pathway |
| positive regulation of cellular response to transforming growth factor beta stimulus |
| histone acetyltransferase binding |
| negative regulation of cyclin-dependent protein kinase activity |
| positive regulation of smooth muscle contraction |
| regulation of smooth muscle cell differentiation |
| smooth muscle cell differentiation |
| myoblast differentiation |
| regulation of cardiac muscle cell differentiation |
| regulation of cardiac muscle cell apoptotic process |
| negative regulation of muscle cell apoptotic process |
| negative regulation of striated muscle cell differentiation |
| regulation of striated muscle cell apoptotic process |
| lung alveolus development |
| positive regulation of cardiac muscle tissue development |
| negative regulation of smooth muscle cell proliferation |
| positive regulation of muscle contraction |
| cellular component maintenance |
| negative regulation of striated muscle tissue development |
| negative regulation of muscle organ development |
| regulation of skeletal muscle tissue development |
| regulation of vascular smooth muscle cell proliferation |
| regulation of cardiocyte differentiation |
| negative regulation of muscle tissue development |
| regulation of myoblast differentiation |
| negative regulation of muscle cell differentiation |
| regulation of histone acetylation |
| positive regulation of DNA binding |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| regulation of smooth muscle contraction |
| regulation of smooth muscle cell migration |
| artery morphogenesis |
| regulation of peptidyl-lysine acetylation |
| vasculogenesis |
| regulation of muscle cell apoptotic process |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| regulation of protein acetylation |
| regulation of cardiac muscle tissue development |
| artery development |
| positive regulation of muscle cell differentiation |
| cardiac muscle cell differentiation |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of striated muscle cell differentiation |
| regulation of cyclin-dependent protein kinase activity |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| histone deacetylase binding |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| cardiocyte differentiation |
| regulation of DNA binding |
| cardiac ventricle development |
| digestive tract development |
| regulation of striated muscle tissue development |
| negative regulation of protein serine/threonine kinase activity |
| regulation of smooth muscle cell proliferation |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| digestive system development |
| regulation of histone modification |
| regulation of muscle cell differentiation |
| stem cell differentiation |
| regulation of muscle contraction |
| cardiac muscle tissue development |
| lung development |
| cardiac chamber development |
| respiratory tube development |
| positive regulation of binding |
| positive regulation of vasculature development |
| regulation of chromatin organization |
| respiratory system development |
| striated muscle cell differentiation |
| negative regulation of protein kinase activity |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of muscle system process |
| nuclear chromatin |
| muscle cell differentiation |
| negative regulation of kinase activity |
| negative regulation of cell migration |
| positive regulation of DNA-binding transcription factor activity |
| cellular response to extracellular stimulus |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| striated muscle tissue development |
| renal system development |
| transcription coactivator activity |
| muscle tissue development |
| negative regulation of cellular component movement |
| urogenital system development |
| regulation of vasculature development |
| negative regulation of locomotion |
| transcription factor binding |
| cellular response to external stimulus |
| response to hypoxia |
| regulation of chromosome organization |
| response to decreased oxygen levels |
| regulation of binding |
| response to oxygen levels |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| regulation of cell growth |
| reproductive structure development |
| regulation of DNA-binding transcription factor activity |
| reproductive system development |
| negative regulation of phosphorylation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| muscle structure development |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| heart development |
| response to extracellular stimulus |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| regulation of system process |
| negative regulation of protein modification process |
| tube morphogenesis |
| developmental process involved in reproduction |
| regulation of growth |
| negative regulation of cell population proliferation |
| negative regulation of cell differentiation |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.404 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3482
- Expression level (log2 read counts): -1.4
Expression Distribution
MYOCD Expression in NALM6 Cells: -1.4
