NACC2
Gene Information
- Official Symbol: N/ACC2
- Official Name: N/ACC family member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 138151
- UniProt: Q96BF6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. {ECO:0000269|PubMed:22926524}.
Pfam Domains GO Terms
Pfam Domains
| BTB |
| BEN |
GO Terms
| negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter |
| positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| cellular protein-containing complex localization |
| histone deacetylase activity |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| histone deacetylation |
| protein deacetylation |
| positive regulation of intrinsic apoptotic signaling pathway |
| protein deacylation |
| macromolecule deacylation |
| positive regulation of response to DNA damage stimulus |
| negative regulation of G1/S transition of mitotic cell cycle |
| negative regulation of cell cycle G1/S phase transition |
| histone deacetylase binding |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of cell cycle G1/S phase transition |
| positive regulation of apoptotic signaling pathway |
| negative regulation of mitotic cell cycle phase transition |
| regulation of response to DNA damage stimulus |
| negative regulation of cell cycle phase transition |
| nuclear chromatin |
| transcription corepressor activity |
| protein-containing complex localization |
| protein-containing complex binding |
| nuclear body |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| protein homooligomerization |
| histone modification |
| covalent chromatin modification |
| regulation of apoptotic signaling pathway |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| protein complex oligomerization |
| negative regulation of cell cycle |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| chromatin organization |
| regulation of cellular response to stress |
| regulation of cell cycle process |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| protein homodimerization activity |
| positive regulation of cell population proliferation |
| positive regulation of intracellular signal transduction |
| chromosome organization |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SGC2043 10μM R03 exp152 | -1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7379
- Expression level (log2 read counts): -1.01
Expression Distribution
NACC2 Expression in NALM6 Cells: -1.01
