NADK2
Gene Information
- Official Symbol: N/ADK2
- Official Name: N/AD kinase 2, mitochondrial
- Aliases and Previous Symbols: N/A
- Entrez ID: 133686
- UniProt: Q4G0N4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
- UniProt Summary: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18059
- Expression level (log2 read counts): 6.21
NADK2 Expression in NALM6 Cells: 6.21
