NBL1
Gene Information
- Official Symbol: NBL1
- Official Name: NBL1, DAN family BMP antagonist
- Aliases and Previous Symbols: N/A
- Entrez ID: 4681
- UniProt: P41271
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Pfam Domains GO Terms
Pfam Domains
| Cys knot |
| DAN |
GO Terms
| sequestering of BMP from receptor via BMP binding |
| sequestering of BMP in extracellular matrix |
| determination of dorsal identity |
| negative regulation of monocyte chemotaxis |
| determination of dorsal/ventral asymmetry |
| maintenance of protein location in extracellular region |
| morphogen activity |
| negative regulation of mononuclear cell migration |
| sequestering of extracellular ligand from receptor |
| extracellular negative regulation of signal transduction |
| BMP binding |
| extracellular regulation of signal transduction |
| negative regulation of leukocyte chemotaxis |
| regulation of monocyte chemotaxis |
| negative regulation of leukocyte migration |
| regulation of mononuclear cell migration |
| negative regulation of BMP signaling pathway |
| negative regulation of chemotaxis |
| dorsal/ventral pattern formation |
| regulation of BMP signaling pathway |
| maintenance of protein location |
| regulation of leukocyte chemotaxis |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| determination of bilateral symmetry |
| specification of symmetry |
| negative regulation of cellular response to growth factor stimulus |
| maintenance of location |
| protein localization to extracellular region |
| regulation of leukocyte migration |
| regulation of chemotaxis |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of cell migration |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell motility |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regionalization |
| negative regulation of response to external stimulus |
| positive regulation of neuron differentiation |
| pattern specification process |
| negative regulation of immune system process |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| positive regulation of nervous system development |
| positive regulation of cell development |
| regulation of neuron differentiation |
| neuron projection development |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| protein homodimerization activity |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| regulation of response to external stimulus |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| generation of neurons |
| extracellular space |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R08 exp434 | 1.91 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7416
- Expression level (log2 read counts): -4.27
Expression Distribution
NBL1 Expression in NALM6 Cells: -4.27
