NDOR1

Entrez Summary: N/A
UniProt Summary: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:20802492, ECO:0000269|PubMed:23596212}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Prochlorperazine 5.2μM R02 exp77	-2.06
AICAR 240μM R05 exp211	-2.04

Gene	Correlation
GEMIN8	0.412

Global Fraction of Cell Lines Where Essential: 411/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	16/28
blood	8/28
bone	14/26
breast	23/33
central nervous system	41/56
cervix	2/4
colorectal	7/17
esophagus	6/13
fibroblast	1/1
gastric	10/16
kidney	17/21
liver	12/20
lung	40/75
lymphocyte	7/16
ovary	20/26
pancreas	10/24
peripheral nervous system	6/16
plasma cell	11/15
prostate	1/1
skin	14/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	6/22
urinary tract	13/29
uterus	3/5

Expression Distribution