NDUFA12
Gene Information
- Official Symbol: NDUFA12
- Official Name: N/ADH:ubiquinone oxidoreductase subunit A12
- Aliases and Previous Symbols: N/A
- Entrez ID: 55967
- UniProt: Q9UI09
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein which is part of mitochondrial complex 1, part of the oxidative phosphorylation system in mitochondria. Complex 1 transfers electrons to ubiquinone from NADH which establishes a proton gradient for the generation of ATP. Mutations in this gene are associated with Leigh syndrome due to mitochondrial complex 1 deficiency. Pseudogenes of this gene are located on chromosomes 5 and 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].
- UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15453
- Expression level (log2 read counts): 5.51
NDUFA12 Expression in NALM6 Cells: 5.51
