NEURL
Gene Information
- Official Symbol: NEURL1
- Official Name: neuralized E3 ubiquitin protein ligase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9148
- UniProt: O76050
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:20847082}.
Pfam Domains GO Terms
Pfam Domains
| Neuralized |
GO Terms
| translation factor activity, non-nucleic acid binding |
| positive regulation of long-term neuronal synaptic plasticity |
| positive regulation of synapse maturation |
| positive regulation of epidermal growth factor-activated receptor activity |
| sperm axoneme assembly |
| regulation of synapse maturation |
| apical dendrite |
| regulation of long-term neuronal synaptic plasticity |
| regulation of epidermal growth factor-activated receptor activity |
| positive regulation of filopodium assembly |
| positive regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of ERBB signaling pathway |
| positive regulation of signaling receptor activity |
| negative regulation of Notch signaling pathway |
| positive regulation of dendritic spine development |
| lactation |
| regulation of filopodium assembly |
| regulation of neuronal synaptic plasticity |
| positive regulation of protein tyrosine kinase activity |
| protein monoubiquitination |
| axoneme assembly |
| cellular response to amino acid stimulus |
| flagellated sperm motility |
| sperm motility |
| regulation of dendritic spine development |
| positive regulation of dendrite development |
| body fluid secretion |
| regulation of epidermal growth factor receptor signaling pathway |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| microtubule bundle formation |
| cilium or flagellum-dependent cell motility |
| cilium-dependent cell motility |
| positive regulation of plasma membrane bounded cell projection assembly |
| regulation of Notch signaling pathway |
| response to amino acid |
| skeletal muscle tissue development |
| Notch signaling pathway |
| mammary gland development |
| skeletal muscle organ development |
| perikaryon |
| dendritic spine |
| regulation of dendrite development |
| spermatid development |
| spermatid differentiation |
| regulation of signaling receptor activity |
| regulation of synaptic plasticity |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of plasma membrane bounded cell projection assembly |
| postsynaptic membrane |
| regulation of cell projection assembly |
| cellular response to acid chemical |
| regulation of synapse organization |
| ubiquitin protein ligase activity |
| regulation of synapse structure or activity |
| ubiquitin-protein transferase activity |
| postsynaptic density |
| regulation of peptidyl-tyrosine phosphorylation |
| germ cell development |
| positive regulation of neuron projection development |
| striated muscle tissue development |
| muscle organ development |
| muscle tissue development |
| response to acid chemical |
| cilium assembly |
| regulation of translation |
| cellular process involved in reproduction in multicellular organism |
| cilium organization |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| regulation of cellular amide metabolic process |
| gland development |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| positive regulation of neurogenesis |
| muscle structure development |
| microtubule cytoskeleton organization |
| regulation of body fluid levels |
| regulation of neuron projection development |
| positive regulation of cellular component biogenesis |
| posttranscriptional regulation of gene expression |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| spermatogenesis |
| cell junction |
| male gamete generation |
| positive regulation of kinase activity |
| cellular response to organonitrogen compound |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| microtubule-based process |
| negative regulation of cell population proliferation |
| protein ubiquitination |
| gamete generation |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| regulation of cell projection organization |
| brain development |
| organelle assembly |
| protein modification by small protein conjugation |
| head development |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| regulation of kinase activity |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| multi-organism reproductive process |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| cytoskeleton organization |
| secretion |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MLN-4924 0.2μM R00 exp21 | -1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14496
- Expression level (log2 read counts): -1.16
Expression Distribution
NEURL Expression in NALM6 Cells: -1.16
