UniProt Summary: E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation. {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
zf-C3HC4
Neuralized
GO Terms
ubiquitin protein ligase activity
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A