NFATC2
Gene Information
- Official Symbol: NFATC2
- Official Name: nuclear factor of activated T cells 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 4773
- UniProt: Q13469
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| TIG |
| RHD |
GO Terms
| negative regulation of vascular smooth muscle cell differentiation |
| calcineurin-NFAT signaling cascade |
| regulation of vascular smooth muscle cell differentiation |
| calcineurin-mediated signaling |
| negative regulation of smooth muscle cell differentiation |
| positive regulation of myoblast fusion |
| regulation of myoblast fusion |
| inositol phosphate-mediated signaling |
| nuclear transcription factor complex |
| positive regulation of syncytium formation by plasma membrane fusion |
| myotube cell development |
| regulation of syncytium formation by plasma membrane fusion |
| regulation of regulatory T cell differentiation |
| regulation of smooth muscle cell differentiation |
| positive regulation of myotube differentiation |
| positive regulation of B cell proliferation |
| phosphatase binding |
| negative regulation of muscle cell differentiation |
| regulation of myotube differentiation |
| myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| regulation of B cell proliferation |
| positive regulation of muscle cell differentiation |
| regulation of striated muscle cell differentiation |
| negative regulation of vasculature development |
| B cell receptor signaling pathway |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| striated muscle cell development |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| calcium-mediated signaling |
| muscle cell development |
| cytokine production |
| regulation of muscle cell differentiation |
| ribonucleoprotein complex |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| Fc-epsilon receptor signaling pathway |
| striated muscle cell differentiation |
| transcription factor complex |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| nuclear chromatin |
| Fc receptor signaling pathway |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| muscle cell differentiation |
| regulation of leukocyte differentiation |
| antigen receptor-mediated signaling pathway |
| regulation of T cell activation |
| regulation of vasculature development |
| transcription factor binding |
| second-messenger-mediated signaling |
| positive regulation of lymphocyte activation |
| chromatin binding |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| muscle structure development |
| immune response-regulating cell surface receptor signaling pathway |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| regulation of lymphocyte activation |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| activation of immune response |
| regulation of cell activation |
| DNA-binding transcription factor activity |
| negative regulation of cell differentiation |
| cellular response to DNA damage stimulus |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| cell migration |
| positive regulation of cell differentiation |
| response to drug |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8876
- Expression level (log2 read counts): 2.33
Expression Distribution
NFATC2 Expression in NALM6 Cells: 2.33
