NME2

Gene Information

Official Symbol: NME2
Official Name: NME/NM23 nucleoside diphosphate kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 4831
UniProt: P22392
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. {ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:8392752}.

Pfam Domains GO Terms

Pfam Domains

NDK

GO Terms

protein histidine kinase activity

peptidyl-histidine phosphorylation

G-quadruplex DNA binding

UTP biosynthetic process

intermediate filament binding

peptidyl-histidine modification

GTP biosynthetic process

UTP metabolic process

CTP metabolic process

guanosine-containing compound biosynthetic process

CTP biosynthetic process

pyrimidine ribonucleoside triphosphate biosynthetic process

positive regulation of keratinocyte differentiation

pyrimidine ribonucleoside triphosphate metabolic process

nucleoside diphosphate kinase activity

pyrimidine nucleoside triphosphate biosynthetic process

pyrimidine ribonucleotide biosynthetic process

ribonucleoside biosynthetic process

purine ribonucleoside biosynthetic process

pyrimidine nucleoside triphosphate metabolic process

purine nucleoside biosynthetic process

fatty acid binding

pyrimidine ribonucleotide metabolic process

positive regulation of epidermal cell differentiation

GTP metabolic process

nucleobase-containing small molecule interconversion

response to growth hormone

cell periphery

positive regulation of epidermis development

nucleoside biosynthetic process

guanosine-containing compound metabolic process

regulation of keratinocyte differentiation

glycosyl compound biosynthetic process

purine ribonucleoside triphosphate biosynthetic process

purine nucleoside triphosphate biosynthetic process

negative regulation of myeloid leukocyte differentiation

pyrimidine nucleotide biosynthetic process

ribonucleoside triphosphate biosynthetic process

cellular response to fatty acid

pyrimidine-containing compound biosynthetic process

positive regulation of epithelial cell differentiation

purine ribonucleoside triphosphate metabolic process

nucleoside diphosphate phosphorylation

purine ribonucleoside metabolic process

regulation of epidermal cell differentiation

nucleotide phosphorylation

pyrimidine nucleotide metabolic process

nucleoside triphosphate biosynthetic process

purine nucleoside metabolic process

ribonucleoside triphosphate metabolic process

purine nucleoside triphosphate metabolic process

cellular response to glucose stimulus

cellular response to hexose stimulus

cellular response to monosaccharide stimulus

GDP binding

ribonucleoside metabolic process

negative regulation of myeloid cell differentiation

cellular response to carbohydrate stimulus

nucleoside diphosphate metabolic process

response to fatty acid

regulation of epidermis development

cellular glucose homeostasis

nucleoside triphosphate metabolic process

ruffle

integrin-mediated signaling pathway

negative regulation of leukocyte differentiation

mitochondrial membrane

pyrimidine-containing compound metabolic process

nucleobase-containing small molecule biosynthetic process

nucleoside metabolic process

regulation of myeloid leukocyte differentiation

secretory granule lumen

intermediate filament

ficolin-1-rich granule lumen

adenylate cyclase-activating G protein-coupled receptor signaling pathway

glycosyl compound metabolic process

negative regulation of hemopoiesis

response to glucose

regulation of epithelial cell differentiation

response to hexose

cAMP-mediated signaling

response to monosaccharide

purine ribonucleotide biosynthetic process

purine nucleotide biosynthetic process

ribonucleotide biosynthetic process

ribose phosphate biosynthetic process

purine-containing compound biosynthetic process

response to carbohydrate

cyclic-nucleotide-mediated signaling

lamellipodium

glucose homeostasis

carbohydrate homeostasis

positive regulation of epithelial cell proliferation

protein autophosphorylation

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

cellular response to acid chemical

regulation of myeloid cell differentiation

cellular response to oxidative stress

nucleotide biosynthetic process

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

nucleoside phosphate biosynthetic process

regulation of leukocyte differentiation

positive regulation of neuron projection development

transcription coactivator activity

purine ribonucleotide metabolic process

ribonucleotide metabolic process

purine nucleotide metabolic process

regulation of epithelial cell proliferation

ribose phosphate metabolic process

second-messenger-mediated signaling

response to acid chemical

enzyme binding

protein serine/threonine kinase activity

purine-containing compound metabolic process

positive regulation of neuron differentiation

positive regulation of cell projection organization

response to oxidative stress

response to peptide hormone

focal adhesion

negative regulation of immune system process

nucleotide metabolic process

nucleoside phosphate metabolic process

regulation of hemopoiesis

positive regulation of neurogenesis

response to peptide

neutrophil degranulation

neutrophil activation involved in immune response

regulation of neuron projection development

neutrophil mediated immunity

neutrophil activation

granulocyte activation

leukocyte degranulation

myeloid leukocyte mediated immunity

protein complex oligomerization

cellular response to lipid

myeloid cell activation involved in immune response

positive regulation of nervous system development

organophosphate biosynthetic process

nucleobase-containing small molecule metabolic process

positive regulation of cell development

myeloid leukocyte activation

small molecule biosynthetic process

carbohydrate derivative biosynthetic process

leukocyte activation involved in immune response

cell activation involved in immune response

regulation of neuron differentiation

regulation of plasma membrane bounded cell projection organization

perinuclear region of cytoplasm

regulated exocytosis

regulation of cell projection organization

negative regulation of cell differentiation

cellular chemical homeostasis

leukocyte mediated immunity

exocytosis

regulation of neurogenesis

response to lipid

peptidyl-amino acid modification

organophosphate metabolic process

negative regulation of apoptotic process

cellular homeostasis

negative regulation of programmed cell death

response to hormone

positive regulation of cell population proliferation

regulation of nervous system development

leukocyte activation

cell adhesion

regulation of cell development

biological adhesion

negative regulation of developmental process

positive regulation of cell differentiation

protein phosphorylation

negative regulation of cell death

response to organonitrogen compound

secretion by cell

carbohydrate derivative metabolic process

export from cell

cellular response to oxygen-containing compound

cell activation

response to nitrogen compound

immune effector process

nucleobase-containing compound biosynthetic process

chemical homeostasis

secretion

heterocycle biosynthetic process

aromatic compound biosynthetic process

negative regulation of multicellular organismal process

positive regulation of cellular component organization

positive regulation of transcription by RNA polymerase II

phosphorylation

organic cyclic compound biosynthetic process

G protein-coupled receptor signaling pathway

positive regulation of developmental process

organonitrogen compound biosynthetic process

DNA binding

response to endogenous stimulus

ATP binding

generation of neurons

positive regulation of transcription, DNA-templated

regulation of apoptotic process

response to oxygen-containing compound

protein-containing complex assembly

regulation of programmed cell death

regulation of cell population proliferation

neurogenesis

cellular nitrogen compound biosynthetic process

positive regulation of nucleic acid-templated transcription

positive regulation of RNA biosynthetic process

homeostatic process

regulation of immune system process

regulation of cell death

intracellular signal transduction

cellular response to stress

positive regulation of RNA metabolic process

positive regulation of multicellular organismal process

small molecule metabolic process

regulation of cell differentiation

protein-containing complex subunit organization

immune response

positive regulation of nucleobase-containing compound metabolic process

positive regulation of macromolecule biosynthetic process

extracellular region

vesicle-mediated transport

positive regulation of cellular biosynthetic process

positive regulation of gene expression

positive regulation of biosynthetic process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Tubastatin-A 2.5μM R07 exp417	-1.84

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15125
Expression level (log2 read counts): 6.34

Expression Distribution