NPFF
Gene Information
- Official Symbol: NPFF
- Official Name: neuropeptide FF-amide peptide precursor
- Aliases and Previous Symbols: N/A
- Entrez ID: 8620
- UniProt: O15130
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. {ECO:0000269|PubMed:11587714}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| somatostatin secretion |
| vasopressin secretion |
| acute inflammatory response to antigenic stimulus |
| negative regulation of heart rate |
| negative regulation of response to food |
| negative regulation of appetite |
| negative regulation of response to nutrient levels |
| negative regulation of response to extracellular stimulus |
| regulation of response to food |
| regulation of appetite |
| inflammatory response to antigenic stimulus |
| negative regulation of heart contraction |
| regulation of response to extracellular stimulus |
| regulation of response to nutrient levels |
| neuropeptide hormone activity |
| response to morphine |
| response to isoquinoline alkaloid |
| negative regulation of blood circulation |
| positive regulation of blood pressure |
| negative regulation of insulin secretion |
| regulation of sensory perception of pain |
| regulation of sensory perception |
| regulation of membrane depolarization |
| negative regulation of peptide hormone secretion |
| axon terminus |
| peptide hormone secretion |
| negative regulation of hormone secretion |
| excitatory postsynaptic potential |
| maternal process involved in female pregnancy |
| G protein-coupled receptor binding |
| chemical synaptic transmission, postsynaptic |
| acute inflammatory response |
| hormone secretion |
| response to anesthetic |
| hormone transport |
| postsynapse |
| regulation of heart rate |
| regulation of postsynaptic membrane potential |
| neuropeptide signaling pathway |
| spinal cord development |
| response to alkaloid |
| negative regulation of protein secretion |
| perikaryon |
| regulation of nervous system process |
| negative regulation of peptide secretion |
| vesicle |
| signal release |
| peptide secretion |
| regulation of insulin secretion |
| female pregnancy |
| regulation of blood pressure |
| negative regulation of protein transport |
| response to ammonium ion |
| negative regulation of establishment of protein localization |
| negative regulation of secretion by cell |
| regulation of peptide hormone secretion |
| multi-multicellular organism process |
| negative regulation of secretion |
| regulation of heart contraction |
| regulation of hormone secretion |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| response to xenobiotic stimulus |
| regulation of cytosolic calcium ion concentration |
| signaling receptor binding |
| negative regulation of response to external stimulus |
| blood circulation |
| circulatory system process |
| chemical synaptic transmission |
| dendrite |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| response to nutrient levels |
| inflammatory response |
| response to extracellular stimulus |
| regulation of hormone levels |
| cellular metal ion homeostasis |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| cellular homeostasis |
| response to organic cyclic compound |
| central nervous system development |
| multi-organism reproductive process |
| response to organonitrogen compound |
| secretion by cell |
| response to drug |
| regulation of protein localization |
| export from cell |
| response to nitrogen compound |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| negative regulation of multicellular organismal process |
| G protein-coupled receptor signaling pathway |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| reproductive process |
| reproduction |
| peptide transport |
| amide transport |
| extracellular space |
| negative regulation of response to stimulus |
| homeostatic process |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5196
- Expression level (log2 read counts): -1.23
Expression Distribution
NPFF Expression in NALM6 Cells: -1.23
