NTAN1
Gene Information
- Official Symbol: NTAN1
- Official Name: N-terminal asparagine amidase
- Aliases and Previous Symbols: N/A
- Entrez ID: 123803
- UniProt: Q96AB6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N- terminal peptidyl Asn. {ECO:0000269|PubMed:21375249}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10619
- Expression level (log2 read counts): 4.58
NTAN1 Expression in NALM6 Cells: 4.58
