NTN1
Gene Information
- Official Symbol: NTN1
- Official Name: netrin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9423
- UniProt: O95631
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. {ECO:0000269|PubMed:15343335}.
Pfam Domains GO Terms
Pfam Domains
| NTR |
| Laminin EGF |
| Laminin N |
GO Terms
| negative regulation of netrin-activated signaling pathway |
| regulation of netrin-activated signaling pathway |
| chemorepulsion of axon |
| Cdc42 protein signal transduction |
| anterior/posterior axon guidance |
| substrate-dependent cell migration, cell extension |
| nuclear migration |
| substrate-dependent cell migration |
| nucleus localization |
| motor neuron axon guidance |
| mammary gland duct morphogenesis |
| negative regulation of axon extension |
| positive regulation of axon extension |
| mammary gland morphogenesis |
| negative chemotaxis |
| mammary gland epithelium development |
| negative regulation of axonogenesis |
| Rho protein signal transduction |
| positive regulation of axonogenesis |
| basement membrane |
| regulation of axon extension |
| negative regulation of cell morphogenesis involved in differentiation |
| inner ear morphogenesis |
| gland morphogenesis |
| dendrite development |
| regulation of synapse assembly |
| negative regulation of developmental growth |
| regulation of extent of cell growth |
| ear morphogenesis |
| neuron migration |
| mammary gland development |
| negative regulation of neuron projection development |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| negative regulation of cell projection organization |
| regulation of cell size |
| negative regulation of cell growth |
| regulation of axonogenesis |
| inner ear development |
| regulation of synapse organization |
| ear development |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| negative regulation of growth |
| Ras protein signal transduction |
| sensory organ morphogenesis |
| positive regulation of growth |
| axon guidance |
| neuron projection guidance |
| positive regulation of neuron projection development |
| embryonic organ morphogenesis |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| small GTPase mediated signal transduction |
| regulation of developmental growth |
| negative regulation of cell development |
| establishment of organelle localization |
| positive regulation of neuron differentiation |
| axonogenesis |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| axon development |
| gland development |
| regulation of cell growth |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| cell-cell adhesion |
| cell part morphogenesis |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| sensory organ development |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| organelle localization |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| apoptotic process |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| cell death |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| intracellular transport |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| establishment of localization in cell |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8545
- Expression level (log2 read counts): 3.3
Expression Distribution
NTN1 Expression in NALM6 Cells: 3.3
