OXSR1
Gene Information
- Official Symbol: OXSR1
- Official Name: oxidative stress responsive kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9943
- UniProt: O95747
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. {ECO:0000269|PubMed:14707132, ECO:0000303|PubMed:14707132}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
| OSR1 C |
GO Terms
| osmosensory signaling pathway |
| signal transduction by trans-phosphorylation |
| chemokine (C-X-C motif) ligand 12 signaling pathway |
| chemokine (C-C motif) ligand 21 signaling pathway |
| cellular hypotonic response |
| hypotonic response |
| positive regulation of T cell chemotaxis |
| regulation of T cell chemotaxis |
| negative regulation of potassium ion transmembrane transporter activity |
| positive regulation of lymphocyte chemotaxis |
| negative regulation of potassium ion transmembrane transport |
| regulation of lymphocyte chemotaxis |
| positive regulation of T cell migration |
| negative regulation of potassium ion transport |
| cellular response to osmotic stress |
| positive regulation of lymphocyte migration |
| regulation of T cell migration |
| regulation of potassium ion transmembrane transporter activity |
| regulation of lymphocyte migration |
| negative regulation of ion transmembrane transporter activity |
| response to osmotic stress |
| negative regulation of transporter activity |
| regulation of potassium ion transmembrane transport |
| chemokine-mediated signaling pathway |
| peptidyl-threonine phosphorylation |
| negative regulation of cation transmembrane transport |
| positive regulation of leukocyte chemotaxis |
| response to chemokine |
| cellular response to chemokine |
| peptidyl-threonine modification |
| regulation of potassium ion transport |
| negative regulation of ion transmembrane transport |
| regulation of leukocyte chemotaxis |
| negative regulation of transmembrane transport |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| stress-activated protein kinase signaling cascade |
| negative regulation of ion transport |
| protein autophosphorylation |
| regulation of leukocyte migration |
| regulation of chemotaxis |
| magnesium ion binding |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| activation of protein kinase activity |
| regulation of cation transmembrane transport |
| protein serine/threonine kinase activity |
| regulation of metal ion transport |
| response to oxidative stress |
| signal transduction by protein phosphorylation |
| protein kinase binding |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| regulation of transmembrane transport |
| positive regulation of kinase activity |
| positive regulation of response to external stimulus |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of ion transport |
| regulation of protein kinase activity |
| regulation of cell migration |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| regulation of cell motility |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| identical protein binding |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| response to abiotic stimulus |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| ATP binding |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinate 1000μM R03 exp140 | -1.89 |
| Myriocin 25μM R06 exp293 | -1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16553
- Expression level (log2 read counts): 6.36
Expression Distribution
OXSR1 Expression in NALM6 Cells: 6.36
