PDLIM3
Gene Information
- Official Symbol: PDLIM3
- Official Name: PDZ and LIM domain 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 27295
- UniProt: Q53GG5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012].
- UniProt Summary: May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7068
- Expression level (log2 read counts): 2.34
PDLIM3 Expression in NALM6 Cells: 2.34
