PGLYRP1
Gene Information
- Official Symbol: PGLYRP1
- Official Name: peptidoglycan recognition protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8993
- UniProt: O75594
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}.
Pfam Domains GO Terms
Pfam Domains
| Amidase 2 |
GO Terms
| growth of symbiont in host |
| growth involved in symbiotic interaction |
| positive regulation of cytolysis in other organism |
| N-acetylmuramoyl-L-alanine amidase activity |
| negative regulation of natural killer cell differentiation involved in immune response |
| phagocytic vesicle lumen |
| regulation of cytolysis in other organism |
| negative regulation of natural killer cell differentiation |
| regulation of natural killer cell differentiation involved in immune response |
| peptidoglycan receptor activity |
| peptidoglycan metabolic process |
| peptidoglycan catabolic process |
| negative regulation of natural killer cell activation |
| positive regulation of cytolysis |
| detection of bacterium |
| regulation of natural killer cell differentiation |
| detection of other organism |
| positive regulation of killing of cells of other organism |
| peptidoglycan binding |
| regulation of cytolysis |
| regulation of killing of cells of other organism |
| detection of external biotic stimulus |
| detection of biotic stimulus |
| regulation of natural killer cell activation |
| negative regulation of interferon-gamma production |
| killing of cells of other organism |
| disruption of cells of other organism |
| negative regulation of lymphocyte differentiation |
| tertiary granule lumen |
| glycosaminoglycan catabolic process |
| specific granule lumen |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| aminoglycan catabolic process |
| positive regulation of cell killing |
| cell killing |
| defense response to Gram-positive bacterium |
| regulation of interferon-gamma production |
| negative regulation of leukocyte differentiation |
| regulation of cell killing |
| antimicrobial humoral response |
| negative regulation of immune effector process |
| pattern recognition receptor signaling pathway |
| negative regulation of inflammatory response |
| negative regulation of hemopoiesis |
| negative regulation of lymphocyte activation |
| negative regulation of immune response |
| glycosaminoglycan metabolic process |
| modification of morphology or physiology of other organism |
| aminoglycan metabolic process |
| regulation of lymphocyte differentiation |
| negative regulation of leukocyte activation |
| carbohydrate derivative catabolic process |
| negative regulation of cell activation |
| negative regulation of defense response |
| innate immune response-activating signal transduction |
| activation of innate immune response |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| defense response to bacterium |
| regulation of inflammatory response |
| positive regulation of innate immune response |
| humoral immune response |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| growth |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| immune response-activating signal transduction |
| myeloid leukocyte activation |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| regulation of cell activation |
| detection of stimulus |
| response to bacterium |
| regulation of cytokine production |
| regulated exocytosis |
| negative regulation of cell differentiation |
| regulation of defense response |
| innate immune response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| symbiotic process |
| exocytosis |
| interspecies interaction between organisms |
| zinc ion binding |
| positive regulation of immune response |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| secretion by cell |
| carbohydrate derivative metabolic process |
| export from cell |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of immune system process |
| organic substance catabolic process |
| regulation of cell differentiation |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TGF-beta1 44ng/ml R08 exp528 | -1.79 |
| Docetaxel 0.002μM R01 exp45 | 1.74 |
| 39°C R06 exp303 | 2.11 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.675 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6527
- Expression level (log2 read counts): -1.98
Expression Distribution
PGLYRP1 Expression in NALM6 Cells: -1.98
