PGLYRP3
Gene Information
- Official Symbol: PGLYRP3
- Official Name: peptidoglycan recognition protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 114771
- UniProt: Q96LB9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:16354652}.
Pfam Domains GO Terms
Pfam Domains
| Amidase 2 |
GO Terms
| growth involved in symbiotic interaction |
| growth of symbiont in host |
| positive regulation of cytolysis in other organism |
| negative regulation of natural killer cell differentiation involved in immune response |
| regulation of cytolysis in other organism |
| negative regulation of natural killer cell differentiation |
| N-acetylmuramoyl-L-alanine amidase activity |
| peptidoglycan receptor activity |
| regulation of natural killer cell differentiation involved in immune response |
| peptidoglycan catabolic process |
| peptidoglycan metabolic process |
| negative regulation of natural killer cell activation |
| positive regulation of cytolysis |
| detection of bacterium |
| regulation of natural killer cell differentiation |
| detection of other organism |
| positive regulation of killing of cells of other organism |
| regulation of killing of cells of other organism |
| peptidoglycan binding |
| regulation of cytolysis |
| detection of external biotic stimulus |
| detection of biotic stimulus |
| regulation of natural killer cell activation |
| negative regulation of interferon-gamma production |
| killing of cells of other organism |
| disruption of cells of other organism |
| negative regulation of lymphocyte differentiation |
| glycosaminoglycan catabolic process |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| aminoglycan catabolic process |
| positive regulation of cell killing |
| cell killing |
| defense response to Gram-positive bacterium |
| regulation of interferon-gamma production |
| negative regulation of leukocyte differentiation |
| regulation of cell killing |
| antimicrobial humoral response |
| negative regulation of immune effector process |
| pattern recognition receptor signaling pathway |
| negative regulation of hemopoiesis |
| negative regulation of lymphocyte activation |
| negative regulation of immune response |
| modification of morphology or physiology of other organism |
| glycosaminoglycan metabolic process |
| aminoglycan metabolic process |
| regulation of lymphocyte differentiation |
| negative regulation of leukocyte activation |
| carbohydrate derivative catabolic process |
| negative regulation of cell activation |
| innate immune response-activating signal transduction |
| activation of innate immune response |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| defense response to bacterium |
| positive regulation of innate immune response |
| humoral immune response |
| positive regulation of response to biotic stimulus |
| growth |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| protein heterodimerization activity |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| protein-containing complex |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| activation of immune response |
| regulation of cell activation |
| detection of stimulus |
| response to bacterium |
| regulation of cytokine production |
| negative regulation of cell differentiation |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| zinc ion binding |
| positive regulation of immune response |
| negative regulation of developmental process |
| defense response to other organism |
| carbohydrate derivative metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of immune system process |
| organic substance catabolic process |
| regulation of cell differentiation |
| immune response |
| extracellular region |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11731
- Expression level (log2 read counts): -6.6
Expression Distribution
PGLYRP3 Expression in NALM6 Cells: -6.6
