PIPOX
Gene Information
- Official Symbol: PIPOX
- Official Name: pipecolic acid and sarcosine oxidase
- Aliases and Previous Symbols: N/A
- Entrez ID: 51268
- UniProt: Q9P0Z9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Metabolizes sarcosine, L-pipecolic acid and L-proline.
Pfam Domains GO Terms
Pfam Domains
| DAO |
GO Terms
| sarcosine oxidase activity |
| L-pipecolate oxidase activity |
| L-lysine catabolic process to acetyl-CoA via L-pipecolate |
| L-lysine catabolic process |
| L-lysine catabolic process to acetyl-CoA |
| L-lysine metabolic process |
| lysine catabolic process |
| lysine metabolic process |
| tetrahydrofolate metabolic process |
| aspartate family amino acid catabolic process |
| folic acid-containing compound metabolic process |
| acetyl-CoA metabolic process |
| pteridine-containing compound metabolic process |
| peroxisomal matrix |
| aspartate family amino acid metabolic process |
| establishment of protein localization to peroxisome |
| protein localization to peroxisome |
| protein targeting to peroxisome |
| peroxisomal transport |
| peroxisome organization |
| acyl-CoA metabolic process |
| thioester metabolic process |
| alpha-amino acid catabolic process |
| peroxisome |
| cellular amino acid catabolic process |
| ribonucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| drug catabolic process |
| cellular modified amino acid metabolic process |
| alpha-amino acid metabolic process |
| coenzyme metabolic process |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| cellular amino acid metabolic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| protein targeting |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| establishment of protein localization to organelle |
| small molecule catabolic process |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| drug metabolic process |
| nucleobase-containing small molecule metabolic process |
| protein localization to organelle |
| cellular amide metabolic process |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| oxidation-reduction process |
| intracellular protein transport |
| oxoacid metabolic process |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| organonitrogen compound catabolic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Phenformin 20μM R03 exp143 | -2.16 |
| Methotrexate 0.01μM R08 exp501 | -1.93 |
| LB-100 4.1μM R02 exp72 | -1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8618
- Expression level (log2 read counts): 2.33
Expression Distribution
PIPOX Expression in NALM6 Cells: 2.33
