PJA1
Gene Information
- Official Symbol: PJA1
- Official Name: praja ring finger ubiquitin ligase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 64219
- UniProt: Q8NG27
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
- UniProt Summary: Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18848
- Expression level (log2 read counts): 3.75
PJA1 Expression in NALM6 Cells: 3.75
