PLIN3
Gene Information
- Official Symbol: PLIN3
- Official Name: perilipin 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10226
- UniProt: O60664
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009].
- UniProt Summary: Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. {ECO:0000269|PubMed:9590177}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5608
- Expression level (log2 read counts): 5.96
PLIN3 Expression in NALM6 Cells: 5.96
