PLSCR1
Gene Information
- Official Symbol: PLSCR1
- Official Name: phospholipid scramblase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5359
- UniProt: O15162
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Pfam Domains GO Terms
Pfam Domains
| Scramblase |
GO Terms
| phosphatidylserine biosynthetic process |
| positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity |
| regulation of DNA topoisomerase (ATP-hydrolyzing) activity |
| CD4 receptor binding |
| regulation of isomerase activity |
| positive regulation of isomerase activity |
| phospholipid scramblase activity |
| regulation of Fc receptor mediated stimulatory signaling pathway |
| plasma membrane phospholipid scrambling |
| response to interferon-beta |
| phosphatidylserine metabolic process |
| epidermal growth factor receptor binding |
| acute-phase response |
| phospholipid translocation |
| lipid translocation |
| regulation of mast cell activation |
| cellular modified amino acid biosynthetic process |
| regulation of membrane lipid distribution |
| positive regulation of ATPase activity |
| negative regulation of viral genome replication |
| acute inflammatory response |
| negative regulation of viral life cycle |
| regulation of ATPase activity |
| phospholipid transport |
| plasma membrane organization |
| regulation of viral genome replication |
| negative regulation of viral process |
| organophosphate ester transport |
| SH3 domain binding |
| platelet activation |
| regulation of viral life cycle |
| defense response to virus |
| cellular modified amino acid metabolic process |
| regulation of viral process |
| glycerophospholipid biosynthetic process |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| glycerolipid biosynthetic process |
| membrane raft |
| phospholipid biosynthetic process |
| response to virus |
| blood coagulation |
| coagulation |
| lipid transport |
| hemostasis |
| glycerophospholipid metabolic process |
| lipid localization |
| positive regulation of innate immune response |
| enzyme binding |
| positive regulation of response to biotic stimulus |
| collagen-containing extracellular matrix |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| endomembrane system organization |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of innate immune response |
| organic anion transport |
| positive regulation of defense response |
| wound healing |
| regulation of body fluid levels |
| inflammatory response |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| organophosphate biosynthetic process |
| response to wounding |
| lipid biosynthetic process |
| anion transport |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| regulation of cell activation |
| perinuclear region of cytoplasm |
| calcium ion binding |
| regulation of defense response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| membrane organization |
| nucleolus |
| positive regulation of immune response |
| organophosphate metabolic process |
| apoptotic process |
| defense response to other organism |
| cellular lipid metabolic process |
| Golgi apparatus |
| programmed cell death |
| cell activation |
| immune effector process |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| regulation of immune response |
| positive regulation of immune system process |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ion transport |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| DNA binding |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Doxycycline 10μM R00 exp18 | 1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15194
- Expression level (log2 read counts): 4.58
Expression Distribution
PLSCR1 Expression in NALM6 Cells: 4.58
