POU3F3
Gene Information
- Official Symbol: POU3F3
- Official Name: POU class 3 homeobox 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5455
- UniProt: P20264
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
| Pou |
GO Terms
| metanephric juxtaglomerular apparatus development |
| macula densa development |
| metanephric DCT cell differentiation |
| DCT cell differentiation |
| metanephric macula densa development |
| juxtaglomerular apparatus development |
| metanephric thick ascending limb development |
| thick ascending limb development |
| metanephric ascending thin limb development |
| ascending thin limb development |
| distal convoluted tubule development |
| metanephric distal convoluted tubule development |
| metanephric loop of Henle development |
| forebrain ventricular zone progenitor cell division |
| metanephric distal tubule development |
| loop of Henle development |
| distal tubule development |
| metanephric nephron tubule development |
| HMG box domain binding |
| cell differentiation involved in metanephros development |
| metanephric nephron epithelium development |
| metanephric tubule development |
| metanephric epithelium development |
| cell proliferation in forebrain |
| cerebral cortex radially oriented cell migration |
| excretion |
| cell differentiation involved in kidney development |
| cerebral cortex cell migration |
| telencephalon cell migration |
| forebrain cell migration |
| neural precursor cell proliferation |
| nephron tubule development |
| renal tubule development |
| metanephros development |
| nephron epithelium development |
| cerebral cortex development |
| nephron development |
| kidney epithelium development |
| pallium development |
| telencephalon development |
| kidney development |
| renal system development |
| urogenital system development |
| forebrain development |
| sequence-specific DNA binding |
| cell division |
| cell population proliferation |
| DNA-binding transcription factor activity |
| brain development |
| head development |
| tube development |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| cell migration |
| central nervous system development |
| negative regulation of cell death |
| localization of cell |
| cell motility |
| chemical homeostasis |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10250
- Expression level (log2 read counts): 3.4
Expression Distribution
POU3F3 Expression in NALM6 Cells: 3.4
