PPIL2
Gene Information
- Official Symbol: PPIL2
- Official Name: peptidylprolyl isomerase like 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 23759
- UniProt: Q13356
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). {ECO:0000250|UniProtKB:Q08752, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952, ECO:0000303|PubMed:8660300}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 866
- Expression level (log2 read counts): 6.4
PPIL2 Expression in NALM6 Cells: 6.4
