PPP1R9A
Gene Information
- Official Symbol: PPP1R9A
- Official Name: protein phosphatase 1 regulatory subunit 9A
- Aliases and Previous Symbols: N/A
- Entrez ID: 55607
- UniProt: Q9ULJ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SAM 2 |
| PDZ |
| SAM 1 |
GO Terms
| negative regulation of spontaneous neurotransmitter secretion |
| growth cone lamellipodium |
| regulation of spontaneous neurotransmitter secretion |
| dendritic spine neck |
| regulation of spontaneous synaptic transmission |
| postsynaptic actin cytoskeleton |
| positive regulation of long-term synaptic depression |
| regulation of synapse structural plasticity |
| negative regulation of long-term synaptic potentiation |
| negative regulation of neurotransmitter secretion |
| postsynaptic actin cytoskeleton organization |
| postsynaptic cytoskeleton organization |
| regulation of long-term synaptic depression |
| protein phosphatase 1 binding |
| negative regulation of stress fiber assembly |
| negative regulation of neurotransmitter transport |
| negative regulation of actin filament bundle assembly |
| GTPase binding |
| positive regulation of dendritic spine development |
| regulation of dendritic spine morphogenesis |
| regulation of long-term synaptic potentiation |
| regulation of filopodium assembly |
| cortical actin cytoskeleton |
| negative regulation of synaptic transmission |
| excitatory postsynaptic potential |
| chemical synaptic transmission, postsynaptic |
| filopodium |
| positive regulation of dendrite development |
| regulation of dendritic spine development |
| neuromuscular junction |
| regulation of stress fiber assembly |
| postsynapse organization |
| regulation of actomyosin structure organization |
| regulation of dendrite morphogenesis |
| regulation of actin filament bundle assembly |
| regulation of postsynapse organization |
| regulation of postsynaptic membrane potential |
| regulation of neurotransmitter secretion |
| regulation of synapse assembly |
| ion channel binding |
| negative regulation of supramolecular fiber organization |
| negative regulation of cytoskeleton organization |
| regulation of neurotransmitter transport |
| calcium-mediated signaling |
| regulation of dendrite development |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| regulation of synaptic plasticity |
| protein C-terminus binding |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| actin filament binding |
| negative regulation of secretion by cell |
| cellular response to toxic substance |
| actin cytoskeleton |
| regulation of synapse organization |
| regulation of protein polymerization |
| regulation of synapse structure or activity |
| negative regulation of secretion |
| actin filament organization |
| protein domain specific binding |
| postsynaptic density |
| regulation of actin filament organization |
| synapse organization |
| aging |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| second-messenger-mediated signaling |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| regulation of neurotransmitter levels |
| positive regulation of neuron differentiation |
| neuronal cell body |
| negative regulation of organelle organization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| dendrite |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| synaptic signaling |
| protein kinase binding |
| positive regulation of neurogenesis |
| negative regulation of transport |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| response to toxic substance |
| regulation of anatomical structure size |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| cell junction |
| actin filament-based process |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| regulation of secretion by cell |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| regulation of kinase activity |
| protein homodimerization activity |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319 | -2.03 |
| QNZ 0.01μM R08 exp439 | -1.76 |
| Rotenone 0.07μM R08 exp431 | 1.76 |
| SGC2043 10μM R03 exp152 | 1.86 |
| SGC0946 7μM R03 exp151 | 2.27 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.412 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5524
- Expression level (log2 read counts): -0.48
Expression Distribution
PPP1R9A Expression in NALM6 Cells: -0.48
