PPP2R2D
Gene Information
- Official Symbol: PPP2R2D
- Official Name: protein phosphatase 2 regulatory subunit Bdelta
- Aliases and Previous Symbols: N/A
- Entrez ID: 55844
- UniProt: Q66LE6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12660
- Expression level (log2 read counts): 5.4
PPP2R2D Expression in NALM6 Cells: 5.4
