PRDM15
Gene Information
- Official Symbol: PRDM15
- Official Name: PR/SET domain 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 63977
- UniProt: P57071
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
GO Terms
| regulation of stem cell division |
| promoter-specific chromatin binding |
| methyltransferase activity |
| positive regulation of canonical Wnt signaling pathway |
| negative regulation of MAPK cascade |
| regulation of cell division |
| positive regulation of Wnt signaling pathway |
| regulation of canonical Wnt signaling pathway |
| nuclear body |
| methylation |
| regulation of Wnt signaling pathway |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| negative regulation of intracellular signal transduction |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| regulation of MAPK cascade |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ARID1A | 0.426 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2928
- Expression level (log2 read counts): 5.59
Expression Distribution
PRDM15 Expression in NALM6 Cells: 5.59
