PSME4
Gene Information
- Official Symbol: PSME4
- Official Name: proteasome activator subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 23198
- UniProt: Q14997
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}.
Pfam Domains GO Terms
Pfam Domains
| DUF3437 |
GO Terms
| spermatoproteasome complex |
| spermatogenesis, exchange of chromosomal proteins |
| peptidase activator activity |
| sperm chromatin condensation |
| proteasome binding |
| lysine-acetylated histone binding |
| spermatid nucleus differentiation |
| proteasomal ubiquitin-independent protein catabolic process |
| histone exchange |
| regulation of cellular amino acid metabolic process |
| regulation of hematopoietic stem cell differentiation |
| ATP-dependent chromatin remodeling |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| regulation of cellular amine metabolic process |
| NIK/NF-kappaB signaling |
| anaphase-promoting complex-dependent catabolic process |
| regulation of hematopoietic progenitor cell differentiation |
| negative regulation of G2/M transition of mitotic cell cycle |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| interleukin-1-mediated signaling pathway |
| Wnt signaling pathway, planar cell polarity pathway |
| antigen processing and presentation of peptide antigen via MHC class I |
| negative regulation of cell cycle G2/M phase transition |
| regulation of establishment of planar polarity |
| stimulatory C-type lectin receptor signaling pathway |
| innate immune response activating cell surface receptor signaling pathway |
| regulation of stem cell differentiation |
| tumor necrosis factor-mediated signaling pathway |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| regulation of DNA-templated transcription in response to stress |
| nucleus organization |
| non-canonical Wnt signaling pathway |
| positive regulation of canonical Wnt signaling pathway |
| spermatid development |
| spermatid differentiation |
| nucleosome organization |
| chromatin remodeling |
| regulation of cellular ketone metabolic process |
| Fc-epsilon receptor signaling pathway |
| negative regulation of canonical Wnt signaling pathway |
| cellular response to interleukin-1 |
| T cell receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen |
| positive regulation of Wnt signaling pathway |
| DNA packaging |
| regulation of mRNA stability |
| regulation of morphogenesis of an epithelium |
| antigen processing and presentation of exogenous antigen |
| regulation of RNA stability |
| cellular response to hypoxia |
| antigen processing and presentation of peptide antigen |
| positive regulation of peptidase activity |
| regulation of G2/M transition of mitotic cell cycle |
| cellular response to decreased oxygen levels |
| response to interleukin-1 |
| regulation of mRNA catabolic process |
| negative regulation of Wnt signaling pathway |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| cellular response to oxygen levels |
| antigen processing and presentation |
| negative regulation of cell cycle phase transition |
| innate immune response-activating signal transduction |
| cellular response to tumor necrosis factor |
| Fc receptor signaling pathway |
| protein-DNA complex subunit organization |
| germ cell development |
| regulation of animal organ morphogenesis |
| activation of innate immune response |
| response to tumor necrosis factor |
| regulation of canonical Wnt signaling pathway |
| protein deubiquitination |
| antigen receptor-mediated signaling pathway |
| protein modification by small protein removal |
| DNA conformation change |
| protein polyubiquitination |
| negative regulation of mitotic cell cycle |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| positive regulation of innate immune response |
| response to hypoxia |
| proteasomal protein catabolic process |
| cellular process involved in reproduction in multicellular organism |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| post-translational protein modification |
| positive regulation of response to biotic stimulus |
| MAPK cascade |
| response to oxygen levels |
| signal transduction by protein phosphorylation |
| nuclear speck |
| regulation of mitotic cell cycle phase transition |
| regulation of small molecule metabolic process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| DNA repair |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| spermatogenesis |
| immune response-activating signal transduction |
| male gamete generation |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| activation of immune response |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| gamete generation |
| chromatin organization |
| regulation of proteolysis |
| DNA metabolic process |
| regulation of cell cycle process |
| regulation of defense response |
| positive regulation of hydrolase activity |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| positive regulation of immune response |
| cellular macromolecule catabolic process |
| protein phosphorylation |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| multi-organism reproductive process |
| cellular response to cytokine stimulus |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| chromosome organization |
| regulation of response to external stimulus |
| response to cytokine |
| cell-cell signaling |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| transmembrane transport |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of response to stress |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mdivi-1 15μM R05 exp217 | -2.49 |
| BVD-523 15μM R02 exp67 | -2.09 |
| Rucaparib 6.5μM R08 exp520 | -2.02 |
| Amiloride 100μM R08 exp447 | 1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4797
- Expression level (log2 read counts): 7.23
Expression Distribution
PSME4 Expression in NALM6 Cells: 7.23
