PTPRA
Gene Information
- Official Symbol: PTPRA
- Official Name: protein tyrosine phosphatase receptor type A
- Aliases and Previous Symbols: N/A
- Entrez ID: 5786
- UniProt: P18433
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Y phosphatase |
GO Terms
| integral component of synaptic membrane |
| transmembrane receptor protein tyrosine phosphatase activity |
| Schaffer collateral - CA1 synapse |
| insulin receptor signaling pathway |
| protein tyrosine phosphatase activity |
| peptidyl-tyrosine dephosphorylation |
| cellular response to insulin stimulus |
| receptor complex |
| protein dephosphorylation |
| response to insulin |
| axon guidance |
| neuron projection guidance |
| cellular response to peptide hormone stimulus |
| dephosphorylation |
| cellular response to peptide |
| MAPK cascade |
| axonogenesis |
| response to peptide hormone |
| signal transduction by protein phosphorylation |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| response to peptide |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| neuron projection development |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| response to hormone |
| protein phosphorylation |
| response to organonitrogen compound |
| neuron differentiation |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| cellular response to endogenous stimulus |
| phosphorylation |
| locomotion |
| integral component of plasma membrane |
| response to endogenous stimulus |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| neurogenesis |
| cell development |
| intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 5μM plus Deferoxamine 11μM R07 exp321 | -2.18 |
| GSK461364A 0.005μM R03 exp125 | 1.95 |
| MLN-4924 0.2μM R00 exp21 | 2.22 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17186
- Expression level (log2 read counts): 6.82
Expression Distribution
PTPRA Expression in NALM6 Cells: 6.82
