PYCR2
Gene Information
- Official Symbol: PYCR2
- Official Name: pyrroline-5-carboxylate reductase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 29920
- UniProt: Q96C36
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012].
- UniProt Summary: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492). {ECO:0000269|PubMed:25865492, ECO:0000269|PubMed:2722838, ECO:0000269|PubMed:6894153}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11676
- Expression level (log2 read counts): 6.86
PYCR2 Expression in NALM6 Cells: 6.86
