RAC3
Gene Information
- Official Symbol: RAC3
- Official Name: Rac family small GTPase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5881
- UniProt: P60763
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}.
Pfam Domains GO Terms
Pfam Domains
| Arf |
| Miro |
| Ras |
GO Terms
| cerebral cortex GABAergic interneuron development |
| regulation of neuron maturation |
| cerebral cortex GABAergic interneuron differentiation |
| engulfment of apoptotic cell |
| GABAergic neuron differentiation |
| synaptic transmission, GABAergic |
| positive regulation of cell adhesion mediated by integrin |
| regulation of cell maturation |
| cerebral cortex neuron differentiation |
| homeostasis of number of cells within a tissue |
| forebrain neuron development |
| filamentous actin |
| positive regulation of substrate adhesion-dependent cell spreading |
| cell periphery |
| apoptotic cell clearance |
| regulation of cell adhesion mediated by integrin |
| forebrain neuron differentiation |
| neuromuscular process controlling balance |
| regulation of substrate adhesion-dependent cell spreading |
| calcium-dependent protein binding |
| actin cytoskeleton reorganization |
| forebrain generation of neurons |
| endomembrane system |
| Rho protein signal transduction |
| central nervous system neuron development |
| positive regulation of actin filament polymerization |
| cell projection |
| neuromuscular process |
| positive regulation of cell-substrate adhesion |
| positive regulation of protein polymerization |
| growth cone |
| phagocytosis, engulfment |
| plasma membrane invagination |
| membrane invagination |
| positive regulation of cell morphogenesis involved in differentiation |
| regulation of actin filament polymerization |
| central nervous system neuron differentiation |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| tissue homeostasis |
| positive regulation of supramolecular fiber organization |
| homeostasis of number of cells |
| regulation of cell-substrate adhesion |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| regulation of cell morphogenesis involved in differentiation |
| small GTPase mediated signal transduction |
| neuron projection |
| multicellular organismal homeostasis |
| phagocytosis |
| GTPase activity |
| anatomical structure homeostasis |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| cytoskeleton |
| neuronal cell body |
| regulation of cellular component size |
| forebrain development |
| regulation of actin filament-based process |
| GTP binding |
| positive regulation of cell adhesion |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| cell projection assembly |
| synaptic signaling |
| protein kinase binding |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| endocytosis |
| actin filament-based process |
| positive regulation of organelle organization |
| regulation of neuron differentiation |
| neuron projection development |
| import into cell |
| regulation of cell adhesion |
| perinuclear region of cytoplasm |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| membrane organization |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| central nervous system development |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| nervous system process |
| generation of neurons |
| movement of cell or subcellular component |
| neurogenesis |
| homeostatic process |
| cell development |
| intracellular signal transduction |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| IL-3 9ng/ml R08 exp493 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5361
- Expression level (log2 read counts): 1.56
Expression Distribution
RAC3 Expression in NALM6 Cells: 1.56
