RASGRF1
Gene Information
- Official Symbol: RASGRF1
- Official Name: Ras protein specific guanine nucleotide releasing factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5923
- UniProt: Q13972
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:11389730}.
Pfam Domains GO Terms
Pfam Domains
| PH |
| RasGEF |
| RasGEF N |
| RhoGEF |
GO Terms
| glutamate receptor binding |
| regulation of Rac protein signal transduction |
| Ras guanyl-nucleotide exchange factor activity |
| long-term memory |
| regulation of NMDA receptor activity |
| regulation of neuronal synaptic plasticity |
| positive regulation of Ras protein signal transduction |
| regulation of glutamate receptor signaling pathway |
| Rho guanyl-nucleotide exchange factor activity |
| positive regulation of small GTPase mediated signal transduction |
| regulation of neurotransmitter receptor activity |
| activation of GTPase activity |
| guanyl-nucleotide exchange factor activity |
| memory |
| growth cone |
| regulation of Rho protein signal transduction |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| regulation of synaptic plasticity |
| regulation of Ras protein signal transduction |
| response to endoplasmic reticulum stress |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| cognition |
| small GTPase mediated signal transduction |
| neuron projection |
| regulation of cation transmembrane transport |
| regulation of small GTPase mediated signal transduction |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| positive regulation of GTPase activity |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of ion transmembrane transport |
| regulation of GTPase activity |
| cell population proliferation |
| regulation of transmembrane transport |
| behavior |
| neuron projection development |
| regulation of ion transport |
| positive regulation of hydrolase activity |
| neuron development |
| protein phosphorylation |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| regulation of hydrolase activity |
| phosphorylation |
| nervous system process |
| positive regulation of catalytic activity |
| generation of neurons |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Doxorubicin 0.02μM R08 exp478 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6297
- Expression level (log2 read counts): -0.03
Expression Distribution
RASGRF1 Expression in NALM6 Cells: -0.03
