UniProt Summary: May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.
Pfam DomainsGO Terms
Pfam Domains
Abhydrolase 6
Abhydrolase 5
DUF1234
GO Terms
hydrolase activity
regulation of cell population proliferation
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)