RHOQ
Gene Information
- Official Symbol: RHOQ
- Official Name: ras homolog family member Q
- Aliases and Previous Symbols: N/A
- Entrez ID: 23433
- UniProt: P17081
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. {ECO:0000269|PubMed:15546864}.
Pfam Domains GO Terms
Pfam Domains
| Miro |
| Arf |
| Ras |
GO Terms
| GBD domain binding |
| profilin binding |
| Golgi-associated vesicle membrane |
| negative regulation of protein localization to plasma membrane |
| negative regulation of protein localization to cell periphery |
| GTP metabolic process |
| negative regulation of protein localization to membrane |
| positive regulation of filopodium assembly |
| positive regulation of glucose import |
| guanosine-containing compound metabolic process |
| cortical actin cytoskeleton organization |
| positive regulation of glucose transmembrane transport |
| regulation of filopodium assembly |
| cortical cytoskeleton organization |
| regulation of glucose import |
| purine ribonucleoside triphosphate metabolic process |
| purine ribonucleoside metabolic process |
| purine nucleoside metabolic process |
| ribonucleoside triphosphate metabolic process |
| purine nucleoside triphosphate metabolic process |
| regulation of glucose transmembrane transport |
| ribonucleoside metabolic process |
| Rho protein signal transduction |
| actin filament |
| insulin receptor signaling pathway |
| nucleoside triphosphate metabolic process |
| regulation of protein localization to plasma membrane |
| cell projection |
| positive regulation of plasma membrane bounded cell projection assembly |
| nucleoside metabolic process |
| negative regulation of cellular protein localization |
| regulation of protein localization to cell periphery |
| glycosyl compound metabolic process |
| cell cortex |
| regulation of cell shape |
| cellular response to insulin stimulus |
| regulation of protein localization to membrane |
| establishment or maintenance of cell polarity |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| positive regulation of transmembrane transport |
| membrane raft |
| response to insulin |
| actin filament organization |
| Ras protein signal transduction |
| cellular response to peptide hormone stimulus |
| purine ribonucleotide metabolic process |
| small GTPase mediated signal transduction |
| ribonucleotide metabolic process |
| cellular response to peptide |
| GTPase activity |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| purine-containing compound metabolic process |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| GTP binding |
| response to peptide hormone |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| supramolecular fiber organization |
| cell projection assembly |
| protein kinase binding |
| response to peptide |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| positive regulation of cellular component biogenesis |
| regulation of cellular protein localization |
| nucleobase-containing small molecule metabolic process |
| regulation of cytoskeleton organization |
| endocytosis |
| regulation of transmembrane transport |
| actin filament-based process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| import into cell |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| organophosphate metabolic process |
| response to hormone |
| regulation of cellular localization |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| response to organonitrogen compound |
| carbohydrate derivative metabolic process |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| cytoskeleton organization |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| intracellular signal transduction |
| positive regulation of RNA metabolic process |
| small molecule metabolic process |
| regulation of intracellular signal transduction |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 11/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6875
- Expression level (log2 read counts): 4.98
Expression Distribution
RHOQ Expression in NALM6 Cells: 4.98
