UniProt Summary: Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
SH3 2
SH3 1
GO Terms
neuromuscular synaptic transmission
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
synapse
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
negative regulation of hydrolase activity
synaptic signaling
cell junction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of catalytic activity
cell-cell signaling
negative regulation of molecular function
regulation of hydrolase activity
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739