UniProt Summary: Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility. {ECO:0000250|UniProtKB:Q3V0F0}.
Pfam DomainsGO Terms
Pfam Domains
SH3 2
GO Terms
benzodiazepine receptor binding
manchette
neuromuscular synaptic transmission
spermatid development
spermatid differentiation
fertilization
germ cell development
cellular process involved in reproduction in multicellular organism
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell-cell signaling
reproductive process
reproduction
cell development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739