UniProt Summary: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase. {ECO:0000250, ECO:0000269|PubMed:16549277}.
Pfam DomainsGO Terms
Pfam Domains
zf-rbx1
zf-C3HC4
PA
GO Terms
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
apoptotic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
programmed cell death
organonitrogen compound catabolic process
cell death
proteolysis
organic substance catabolic process
cellular catabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)