RPS18
Gene Information
- Official Symbol: RPS18
- Official Name: ribosomal protein S18
- Aliases and Previous Symbols: N/A
- Entrez ID: 6222
- UniProt: P62269
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S13 |
GO Terms
| small ribosomal subunit |
| rRNA binding |
| ribosome |
| cytosolic small ribosomal subunit |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| RNA catabolic process |
| postsynaptic density |
| establishment of protein localization to membrane |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| organic cyclic compound catabolic process |
| protein localization to membrane |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Salinomycin 3.5μM R08 exp521 | -2.03 |
| TIC10 10μM R08 exp532 | -1.99 |
| Amiloride 100μM R08 exp447 | -1.91 |
| Nocodazole 0.2μM R02 exp64 | -1.82 |
| Phenformin 20μM R03 exp143 | -1.78 |
| iCRT14 30μM R08 exp492 | -1.75 |
| SNS-032 15μM R08 exp443 | -1.75 |
| Aminopterin 0.005μM R07 exp335 | 1.8 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 624/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 24/28 |
| blood | 20/28 |
| bone | 22/26 |
| breast | 29/33 |
| central nervous system | 51/56 |
| cervix | 3/4 |
| colorectal | 16/17 |
| esophagus | 10/13 |
| fibroblast | 0/1 |
| gastric | 14/16 |
| kidney | 17/21 |
| liver | 18/20 |
| lung | 64/75 |
| lymphocyte | 14/16 |
| ovary | 24/26 |
| pancreas | 22/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 13/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 14/22 |
| urinary tract | 23/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 881
- Expression level (log2 read counts): 9.99
Expression Distribution
RPS18 Expression in NALM6 Cells: 9.99
