RPS27L
Gene Information
- Official Symbol: RPS27L
- Official Name: ribosomal protein S27 like
- Aliases and Previous Symbols: N/A
- Entrez ID: 51065
- UniProt: Q71UM5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S27e |
GO Terms
| translation activator activity |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| DNA damage response, signal transduction resulting in transcription |
| cysteine-type endopeptidase activator activity involved in apoptotic process |
| ribosomal small subunit assembly |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| cytosolic small ribosomal subunit |
| intrinsic apoptotic signaling pathway by p53 class mediator |
| mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| G1 DNA damage checkpoint |
| ribosome assembly |
| ribosomal small subunit biogenesis |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| DNA damage response, signal transduction by p53 class mediator |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitotic DNA damage checkpoint |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| signal transduction by p53 class mediator |
| positive regulation of translation |
| DNA damage checkpoint |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| DNA integrity checkpoint |
| intrinsic apoptotic signaling pathway |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of cellular amide metabolic process |
| positive regulation of cysteine-type endopeptidase activity |
| mitotic cell cycle checkpoint |
| regulation of cell cycle G1/S phase transition |
| structural constituent of ribosome |
| positive regulation of endopeptidase activity |
| positive regulation of peptidase activity |
| cell cycle checkpoint |
| negative regulation of mitotic cell cycle phase transition |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cell cycle phase transition |
| ribonucleoprotein complex assembly |
| regulation of cysteine-type endopeptidase activity |
| ribonucleoprotein complex subunit organization |
| apoptotic signaling pathway |
| ribosome biogenesis |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| regulation of translation |
| positive regulation of proteolysis |
| translation |
| regulation of cellular amide metabolic process |
| peptide biosynthetic process |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| ribonucleoprotein complex biogenesis |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| mitotic cell cycle |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of cell cycle process |
| organelle assembly |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| cellular amide metabolic process |
| cellular protein-containing complex assembly |
| apoptotic process |
| cell cycle process |
| programmed cell death |
| cell death |
| regulation of cell cycle |
| regulation of hydrolase activity |
| cell cycle |
| RNA binding |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0129480 7μM R02 exp85 | -1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3793
- Expression level (log2 read counts): 5.54
Expression Distribution
RPS27L Expression in NALM6 Cells: 5.54
