RPS6KA1
Gene Information
- Official Symbol: RPS6KA1
- Official Name: ribosomal protein S6 kinase A1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6195
- UniProt: Q15418
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
| Pkinase C |
| Kdo |
GO Terms
| hepatocyte proliferation |
| epithelial cell proliferation involved in liver morphogenesis |
| positive regulation of hepatic stellate cell activation |
| liver morphogenesis |
| regulation of hepatic stellate cell activation |
| ribosomal protein S6 kinase activity |
| regulation of translation in response to stress |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| protein serine/threonine/tyrosine kinase activity |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| epithelial cell proliferation |
| negative regulation of cysteine-type endopeptidase activity |
| gland morphogenesis |
| regulation of DNA-templated transcription in response to stress |
| liver development |
| hepaticobiliary system development |
| positive regulation of cell growth |
| magnesium ion binding |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| positive regulation of growth |
| regulation of translation |
| negative regulation of proteolysis |
| protein serine/threonine kinase activity |
| regulation of cellular amide metabolic process |
| gland development |
| positive regulation of cell activation |
| regulation of cell growth |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| posttranscriptional regulation of gene expression |
| cell population proliferation |
| regulation of cell activation |
| regulation of growth |
| regulation of proteolysis |
| negative regulation of catalytic activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cell death |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| positive regulation of transcription by RNA polymerase II |
| regulation of hydrolase activity |
| phosphorylation |
| cell cycle |
| positive regulation of developmental process |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Arsenate 40μM R06 exp264 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8403
- Expression level (log2 read counts): 5.98
Expression Distribution
RPS6KA1 Expression in NALM6 Cells: 5.98
