SCARA5
Gene Information
- Official Symbol: SCARA5
- Official Name: scavenger receptor class A member 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 286133
- UniProt: Q6ZMJ2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). {ECO:0000255|HAMAP- Rule:MF_03070}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12415
- Expression level (log2 read counts): -0.61
SCARA5 Expression in NALM6 Cells: -0.61
