Entrez Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
ASC
GO Terms
sodium channel complex
sodium channel activity
ligand-gated sodium channel activity
ion channel activity
WW domain binding
sodium ion homeostasis
excretion
multicellular organismal water homeostasis
sensory perception of taste
water homeostasis
sodium ion transmembrane transport
monovalent inorganic cation homeostasis
sodium ion transport
apical plasma membrane
multicellular organismal homeostasis
external side of plasma membrane
monovalent inorganic cation transport
regulation of body fluid levels
sensory perception of chemical stimulus
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
metal ion transport
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
ion homeostasis
cation transport
ion transmembrane transport
sensory perception
chemical homeostasis
transmembrane transport
ion transport
nervous system process
integral component of plasma membrane
homeostatic process
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)