SEMG2
Gene Information
- Official Symbol: SEMG2
- Official Name: semenogelin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6407
- UniProt: Q02383
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
Pfam Domains GO Terms
Pfam Domains
| Semenogelin |
GO Terms
| positive regulation of serine-type peptidase activity |
| positive regulation of serine-type endopeptidase activity |
| negative regulation of cilium-dependent cell motility |
| negative regulation of flagellated sperm motility |
| regulation of serine-type peptidase activity |
| regulation of serine-type endopeptidase activity |
| regulation of flagellated sperm motility |
| regulation of cilium-dependent cell motility |
| sperm capacitation |
| antibacterial humoral response |
| negative regulation of reproductive process |
| protease binding |
| protein heterooligomerization |
| antimicrobial humoral response |
| spermatid development |
| spermatid differentiation |
| cell maturation |
| regulation of reproductive process |
| positive regulation of endopeptidase activity |
| positive regulation of peptidase activity |
| developmental maturation |
| germ cell development |
| negative regulation of cell motility |
| coagulation |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| defense response to bacterium |
| humoral immune response |
| cellular process involved in reproduction in multicellular organism |
| positive regulation of proteolysis |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| protein complex oligomerization |
| spermatogenesis |
| male gamete generation |
| developmental process involved in reproduction |
| response to bacterium |
| gamete generation |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| zinc ion binding |
| multicellular organism reproduction |
| regulation of cell motility |
| defense response to other organism |
| regulation of locomotion |
| regulation of cellular component movement |
| multi-organism reproductive process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| protein-containing complex assembly |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| cell development |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15108
- Expression level (log2 read counts): -7.68
Expression Distribution
SEMG2 Expression in NALM6 Cells: -7.68
