SERPINA7
Gene Information
- Official Symbol: SERPINA7
- Official Name: serpin family A member 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 6906
- UniProt: P05543
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012].
- UniProt Summary: Major thyroid hormone transport protein in serum.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17730
- Expression level (log2 read counts): -7.68
SERPINA7 Expression in NALM6 Cells: -7.68
