SEZ6
Gene Information
- Official Symbol: SEZ6
- Official Name: seizure related 6 homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 124925
- UniProt: Q53EL9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016].
- UniProt Summary: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6002
- Expression level (log2 read counts): 1.16
SEZ6 Expression in NALM6 Cells: 1.16
