SH2D3C
Gene Information
- Official Symbol: SH2D3C
- Official Name: SH2 domain containing 3C
- Aliases and Previous Symbols: N/A
- Entrez ID: 10044
- UniProt: Q8N5H7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
- UniProt Summary: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9459
- Expression level (log2 read counts): 4.89
SH2D3C Expression in NALM6 Cells: 4.89
