SHISA6
Gene Information
- Official Symbol: SHISA6
- Official Name: shisa family member 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 388336
- UniProt: Q6ZSJ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| regulation of AMPA glutamate receptor clustering |
| regulation of glutamate receptor clustering |
| asymmetric, glutamatergic, excitatory synapse |
| excitatory chemical synaptic transmission |
| neurotransmitter receptor diffusion trapping |
| receptor diffusion trapping |
| postsynaptic neurotransmitter receptor diffusion trapping |
| regulation of receptor clustering |
| regulation of postsynaptic neurotransmitter receptor activity |
| protein localization to postsynaptic specialization membrane |
| dendritic spine membrane |
| neurotransmitter receptor localization to postsynaptic specialization membrane |
| regulation of postsynaptic membrane organization |
| regulation of short-term neuronal synaptic plasticity |
| regulation of AMPA receptor activity |
| AMPA glutamate receptor complex |
| ionotropic glutamate receptor binding |
| protein localization to postsynaptic membrane |
| receptor localization to synapse |
| regulation of postsynaptic membrane neurotransmitter receptor levels |
| integral component of postsynaptic density membrane |
| regulation of neuronal synaptic plasticity |
| protein localization to synapse |
| regulation of glutamate receptor signaling pathway |
| regulation of neurotransmitter receptor activity |
| localization within membrane |
| PDZ domain binding |
| regulation of postsynapse organization |
| regulation of nervous system process |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| negative regulation of canonical Wnt signaling pathway |
| regulation of synaptic plasticity |
| regulation of protein localization to membrane |
| postsynaptic membrane |
| negative regulation of Wnt signaling pathway |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| protein localization to cell periphery |
| postsynaptic density |
| protein-containing complex localization |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| synapse |
| regulation of transporter activity |
| regulation of canonical Wnt signaling pathway |
| regulation of cation transmembrane transport |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| regulation of cellular protein localization |
| spermatogenesis |
| cell junction |
| regulation of transmembrane transport |
| male gamete generation |
| regulation of system process |
| gamete generation |
| regulation of ion transport |
| protein localization to organelle |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| regulation of cellular localization |
| multi-organism reproductive process |
| regulation of protein localization |
| cell-cell signaling |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| cellular protein localization |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| QNZ 0.01μM R05 exp241 | -1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11020
- Expression level (log2 read counts): -1.98
Expression Distribution
SHISA6 Expression in NALM6 Cells: -1.98
