SLC39A14
Gene Information
- Official Symbol: SLC39A14
- Official Name: solute carrier family 39 member 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 23516
- UniProt: Q15043
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017].
- UniProt Summary: Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. {ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:27231142}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4271
- Expression level (log2 read counts): 7.92
SLC39A14 Expression in NALM6 Cells: 7.92
