SMURF1
Gene Information
- Official Symbol: SMURF1
- Official Name: SMAD specific E3 ubiquitin protein ligase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 57154
- UniProt: Q9HCE7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23999003}.
Pfam Domains GO Terms
Pfam Domains
| HECT |
| WW |
| C2 |
GO Terms
| engulfment of target by autophagosome |
| substrate localization to autophagosome |
| protein targeting to vacuole involved in autophagy |
| parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization |
| ubiquitin-dependent SMAD protein catabolic process |
| positive regulation of mitophagy in response to mitochondrial depolarization |
| positive regulation of mitophagy |
| I-SMAD binding |
| positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
| regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
| activin binding |
| regulation of mitophagy |
| response to mitochondrial depolarisation |
| positive regulation of autophagy of mitochondrion |
| ectoderm development |
| R-SMAD binding |
| positive regulation of dendrite extension |
| protein localization to cell surface |
| regulation of dendrite extension |
| receptor catabolic process |
| protein targeting to vacuole |
| regulation of autophagy of mitochondrion |
| establishment of protein localization to vacuole |
| negative regulation of BMP signaling pathway |
| autophagosome assembly |
| protein localization to vacuole |
| autophagosome organization |
| positive regulation of macroautophagy |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of ossification |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| regulation of BMP signaling pathway |
| BMP signaling pathway |
| Wnt signaling pathway, planar cell polarity pathway |
| positive regulation of ubiquitin-dependent protein catabolic process |
| transforming growth factor beta receptor signaling pathway |
| cellular response to BMP stimulus |
| phospholipid binding |
| receptor metabolic process |
| response to BMP |
| regulation of establishment of planar polarity |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| positive regulation of mitochondrion organization |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of autophagy |
| vacuole organization |
| non-canonical Wnt signaling pathway |
| positive regulation of cellular protein catabolic process |
| vacuolar transport |
| membrane invagination |
| negative regulation of cellular response to growth factor stimulus |
| protein export from nucleus |
| regulation of ubiquitin-dependent protein catabolic process |
| cellular response to transforming growth factor beta stimulus |
| nuclear export |
| macroautophagy |
| response to transforming growth factor beta |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| regulation of macroautophagy |
| regulation of mitochondrion organization |
| regulation of morphogenesis of an epithelium |
| protein localization to plasma membrane |
| regulation of ossification |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of protein catabolic process |
| ubiquitin protein ligase activity |
| protein localization to cell periphery |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| ubiquitin-protein transferase activity |
| regulation of cellular protein catabolic process |
| regulation of animal organ morphogenesis |
| positive regulation of growth |
| process utilizing autophagic mechanism |
| autophagy |
| nucleocytoplasmic transport |
| nuclear transport |
| regulation of cellular response to growth factor stimulus |
| positive regulation of neuron projection development |
| axon |
| protein polyubiquitination |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| regulation of developmental growth |
| regulation of autophagy |
| proteasomal protein catabolic process |
| Wnt signaling pathway |
| positive regulation of proteolysis |
| cell-cell signaling by wnt |
| protein targeting |
| positive regulation of cellular catabolic process |
| positive regulation of neuron differentiation |
| neuronal cell body |
| positive regulation of cell projection organization |
| regulation of protein catabolic process |
| regulation of cell growth |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| establishment of protein localization to organelle |
| positive regulation of catabolic process |
| positive regulation of neurogenesis |
| protein localization to membrane |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| ubiquitin-dependent protein catabolic process |
| response to growth factor |
| modification-dependent protein catabolic process |
| positive regulation of nervous system development |
| positive regulation of cell development |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| positive regulation of organelle organization |
| regulation of neuron differentiation |
| regulation of growth |
| protein catabolic process |
| protein ubiquitination |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| protein localization to organelle |
| organelle assembly |
| protein modification by small protein conjugation |
| regulation of neurogenesis |
| regulation of cellular catabolic process |
| membrane organization |
| cellular macromolecule catabolic process |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| mitochondrion |
| negative regulation of signal transduction |
| proteolysis |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8549
- Expression level (log2 read counts): 5.3
Expression Distribution
SMURF1 Expression in NALM6 Cells: 5.3
