UniProt Summary: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Reeler
GO Terms
LBD domain binding
negative regulation of amyloid-beta formation
negative regulation of amyloid precursor protein catabolic process
positive regulation of amyloid precursor protein catabolic process
positive regulation of protein processing
positive regulation of protein maturation
regulation of amyloid-beta formation
regulation of amyloid precursor protein catabolic process
regulation of protein processing
regulation of protein maturation
positive regulation of protein binding
extracellular matrix structural constituent
negative regulation of cellular amide metabolic process
positive regulation of binding
regulation of protein binding
extracellular matrix
endoplasmic reticulum lumen
positive regulation of proteolysis
collagen-containing extracellular matrix
regulation of binding
regulation of cellular amide metabolic process
regulation of proteolysis
cell adhesion
biological adhesion
negative regulation of protein metabolic process
extracellular space
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
positive regulation of gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A