STOX1
Gene Information
- Official Symbol: STOX1
- Official Name: storkhead box 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 219736
- UniProt: Q6ZVD7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Stork head |
GO Terms
| regulation of otic vesicle morphogenesis |
| positive regulation of otic vesicle morphogenesis |
| regulation of mitochondrial DNA metabolic process |
| cellular response to nitrosative stress |
| response to nitrosative stress |
| positive regulation of G2/M transition of mitotic cell cycle |
| positive regulation of peptidyl-threonine phosphorylation |
| positive regulation of cell cycle G2/M phase transition |
| positive regulation of morphogenesis of an epithelium |
| positive regulation of cyclin-dependent protein kinase activity |
| positive regulation of embryonic development |
| regulation of peptidyl-threonine phosphorylation |
| regulation of mitochondrial membrane potential |
| positive regulation of mitotic cell cycle phase transition |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| positive regulation of animal organ morphogenesis |
| regulation of response to oxidative stress |
| positive regulation of cell cycle phase transition |
| regulation of cyclin-dependent protein kinase activity |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| regulation of DNA-templated transcription in response to stress |
| regulation of embryonic development |
| fibrillar center |
| cell cortex |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of mitotic cell cycle |
| positive regulation of protein kinase B signaling |
| regulation of morphogenesis of an epithelium |
| regulation of mitochondrion organization |
| cellular response to hypoxia |
| positive regulation of epithelial cell proliferation |
| inner ear development |
| regulation of G2/M transition of mitotic cell cycle |
| cellular response to decreased oxygen levels |
| regulation of cell cycle G2/M phase transition |
| cellular response to oxygen levels |
| regulation of protein kinase B signaling |
| ear development |
| regulation of animal organ morphogenesis |
| positive regulation of cell cycle process |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of epithelial cell proliferation |
| response to hypoxia |
| regulation of DNA metabolic process |
| response to decreased oxygen levels |
| positive regulation of cell cycle |
| response to oxygen levels |
| regulation of mitotic cell cycle phase transition |
| regulation of membrane potential |
| regulation of cell cycle phase transition |
| centrosome |
| cell division |
| positive regulation of protein kinase activity |
| sensory organ development |
| positive regulation of kinase activity |
| regulation of mitotic cell cycle |
| positive regulation of transferase activity |
| regulation of cell cycle process |
| regulation of protein kinase activity |
| regulation of kinase activity |
| positive regulation of cell population proliferation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of protein modification process |
| regulation of organelle organization |
| cell cycle |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vinblastine 0.2μM R03 exp108 | 1.72 |
| Talazoparib 0.006μM R06 exp299 | 1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18206
- Expression level (log2 read counts): 3.36
Expression Distribution
STOX1 Expression in NALM6 Cells: 3.36
